RESUMO
Primary frozen shoulder (PFS) is a common condition of uncertain etiology that is characterized by shoulder pain and restriction of active and passive glenohumeral motions. The pathophysiology involves chronic inflammation and fibrosis of the joint capsule. Single nucleotide polymorphisms (SNPs) at IL-1ß, MMP3, TGF-ß1, and GDF5 have been associated with risk of a variety of inflammatory diseases; however, no studies have examined these SNPs with susceptibility to PFS. We investigated allele and genotype frequencies of rs1143627 at IL-1ß, rs650108 at MMP-3, rs1800469 at TGF-ß1, and rs143383 at GDF5 in 42 patients with PFS and 50 healthy controls in a Chinese Han population. Serum samples from both cohorts were evaluated to determine the expression levels of IL-1ß. We found that the IL-1ß rs1143627 CC genotype was associated with a decreased risk of PFS compared to the TT genotype (P = 0.022) and that serum IL-1ß was expressed at a significantly higher level in the PFS cohort compared to that found in the control group (P < 0.001). Our findings indicated no evidence of an association between rs650108, rs1800469, or rs143383 and PFS. IL-1ß is associated with susceptibility to PFS and may have a role in its pathogenesis in a Chinese Han population.
Assuntos
Bursite/genética , Predisposição Genética para Doença , Fator 5 de Diferenciação de Crescimento/genética , Interleucina-1beta/genética , Metaloproteinase 3 da Matriz/genética , Polimorfismo de Nucleotídeo Único , Povo Asiático/etnologia , Povo Asiático/genética , Bursite/etnologia , China/etnologia , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
A lesão de Morel-Lavallée é uma lesão em cisalhamento que ocorre entre o tecido celular subcutâneo e a fáscia profunda. Caracteriza-se pela formação de uma coleção que, originalmente descrita na coxa, vem sendo observada em outros locais. Os autores relatam o caso de paciente com Morel-Lavallée no joelho e descrevem as principais características desta lesão.
Morel-Lavallée lesion is a degloving injury of the interface between the subcutaneous fat and the underlying fascia. This lesion is characterized by the development of a fluid collection that, although originally described in the thigh, it has also been described in other anatomical sites. The authors report the case of a patient with Morel-Lavallée lesion in the knee after trauma and describe the main characteristics of the lesion.
